Mystery of kidney stone removal report review solved

"kidney stone removal report review" Now we finally have a complete picture detail why some people develop kidney stones and others do not," said lead author Shijiazhuang Sou, PhD, assistant professor of medicine.

"With this information we can start thinking about better treatments and ways of thinking about a person's risk status, which generally determine increases with age," said Ho.
The study was conducted in mice. As renal function in the same way in mice and humans, the new findings will help researchers to the causes of kidney stones in patients.

The mouse model used in the study may also serve as a platform for preclinical testing of new treatments for this disease, the researchers noted.

Most kidney stones form when urine concentrating crystallizing minerals like calcium and stick together. Diet plays a role in the state - not enough water to drink or eat too much salt (which binds to calcium) also increases the risk calculations.

But genes are part of the debt. kidney stone removal report an unbiased review Been a common genetic variation in a gene called claudin-14 has recently made a significant increased risk associated - some 65 percent - to get kidney stones. In the new study, researchers showed how changes  in gene activity in the development of stones.

Generally, the claudin-14 gene is not active in the kidney. New research shows that expression of two RNA fragments, a sister of the DNA molecule that essentially carry the silent gene is attenuated.
When claudin-14 is inactive, the kidney filtration system works as it should. Essential minerals like calcium and magnesium in the blood passes through the kidney and back into the bloodstream where they are transported to the cells that perform basic functions of life are absorbed.

But when people eat a diet rich in calcium or salt and drinking water is not sufficient to dissolve small RNA molecules, their influence on Claudina 14th An increased activity prevents the gene showed that calcium from re-entry into the blood of the study.

Hou and his team found that claudin-14, calcium entry blockers programs called tight junctions in cells expressing the isolated kidney and blood in the urine.
Without a way back into the bloodstream, the excess calcium passes into the urine. Too much calcium in the urine can lead to kidney stones or bladder. Severe pain occurs when a large stone in the bladder, ureters or blocks the urethra and insert the flow of urine remains.

Hou research supports the theory that human beings with a common variation regulate claudin-14 capacity, the activity of the gene, thus losing the risk of kidney stones.

But he is optimistic that drugs could be developed to target short segments of RNA, which are closely related to drugs that can mimic kidney stone removal report review conclusion Claudine 14th this so-called micro-RNA, the activity of claudin-14 to hold in check and reduce the likelihood that the stones are formed.

In addition, it may one day be possible to develop a diagnostic test for levels of claudin-14 protein in the urine to measure excretion. Higher values ​​indicate an increased risk of stones, and people could take steps to prevent the calculations by changing their diet.

"Many genes probably play a role in the formation of kidney stones," said Hon.

"But this study gives us a better idea of ​​how a leading labor. However, as we understand the physiology of the disease, we can start thinking about better treatments or even ways of stones from developing countries to avoid the first line, thinking, "he added.