New Research Discovers Cause Of kidney stone removal report review

A strong irritation near the stomach. The feeling of pain in the back. The discovery of blood in the urine. These are just some of the symptoms of kidney stones. An estimated one million people suffer from kidney stones each year. It was recently revealed more information, done against the cause of kidney stones through research of scientists at the University of Washington School of Medicine in St. Louis, Missouri.

The research found in the EMBOSS Journal European Molecular Biology Organization, provides reasons why some people are more prone to kidney stones than others. 

The results allow the development of effective treatments and tests that would assess the risk of a person with the disease. Mice were used in the study and can be used in clinical trials of new therapies for kidney stones.

"Now we finally have a complete picture detail why some people develop kidney stones and others do not," said lead author Shijiazhuang"kidney stone removal report review conclusion" Hon, PhD, assistant professor of medicine, prepared in a statement. "With this information, we can start thinking about better treatments and ways to reduce the risk of a person over the state, which generally increases with the age determined to think. "

In general, shops kidney shape, if the urine is too concentrated, causing minerals such as calcium, to unite. Dietary factors, such as drinking eating foods high in salt or too little can increase the risk of kidney stones.

In addition to nutritional concerns, the researchers show that genes play a role in the formation of kidney stones. Claudin-14, a genetic variation has been linked to kidney stones, in combination and those who have the mutation, a 65 percent chance of more stones. The new study has shown how differences in gene activity may affect the"kidney stone removal report review". When claudin-14 is not active, the kidney is normal and important minerals like calcium and magnesium, can easily occur. These minerals are then in the bloodstream, where they are absorbed in the support functions of the base. However, if people eat too many salty foods or drink enough water, work begins claudin-14. It prevents the penetration of calcium "tight junctions" in the cells lining the kidney and can not effectively separated from the blood in the urine. The excess calcium then filtered into the urine, leading to kidney stones in the bladder or kidneys.

Based on his research, believes that treatments could be developed Hon are focused on the activity of caludin-14. He is also optimistic that the tests could be created to analyze the level of Claudin-14 and determine the ability of stones. These tests can identify patients who need to change parts of their diet.

"Many genes probably play a role in the formation of kidney stones," Hon said in the statement. "But this study gives us a better idea of ​​how one of the main actors of work. However, as we understand physiology of the disease, we can start thinking about better treatments or even ways of stones from developing countries in order to avoid the first line of thought. "...